trifectUserMessage

billToLabel

nonTrifectaUserMessage

requireAuthentication

unValidatedMessage

unregisteredMessage

requireRegistration

requiresValidation

unauthenticatedMessage

siteLink

siteLogo

headerLinks

Header Links

parentCompanyLink

mainSiteLink

footerLinks

Footer Links

copyrights

opcoLogos

Opco Logos

trademarks

parentCompanyLogo

mainSiteLinkText

regulatory

siteRobotsTXT

gtmId

footerGTMScript

headerGTMScript

Content Source Notes

MAPSS Code

Alert banners

Outage Alert

isExternal

description

title

style

checkCommerceEnabled

Copyright

Legal

Online Terms of Use

Patents

Privacy Statement

Sitemap

Danaher Life Sciences

Dashboard

Quotes

Scheduled Orders

Order History

order-center

redeemQuotePage

CD184 (also known as CXCR4, or Fusin) is a seven-transmembrane domain G protein-coupled surface receptor. CD184 (CXCR4) natural ligand is the stromal cell-derived factor-1 (SDF-1), a C-X-C chemokine (the nomenclature specifies that this chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif), which is strongly chemotactic for monocytes and lymphocytes. But CD184 (CXCR4) has also initially been described as the human immunodeficiency virus-1 (HIV-1) entry co-receptor, associated with the surface CD4-gp120 complex before HIV-1 enters target cells. It also acts as an alternative receptor for some isolates of HIV-2. The SDF-1 / CXCR4 pair may also play a role in the development of the nervous system. Unlike other chemokine receptors, the cellular distribution of CD184 (CXCR4) is nearly ubiquitous; it is expressed on a variety of CD4+ and CD4– cells in the immune system and the central nervous system. In blood, CD184 (CXCR4) is highly expressed on neutrophils, monocytes, dendritic cells, NK cells, B cells, and T cells, as well as on platelets. CD184 (CXCR4) exhibits a rapid (30 seconds) up-regulation upon activation of lymphocytes, followed by internalization (within 2 minutes). Accordingly, CD184 (CXCR4) is detected in large amounts in intracellular stores within leucocytes. Absent from eosinophils and basophils in fresh whole blood, CD184 (CXCR4) is inducible ex vivo on eosinophils by glucocorticoids, and on basophils by SDF-1. As a GPCR, CXCR4 binding of SDF-1 triggers certain signaling pathways such as ras, and PI3 kinase. One downstream effect of SDF-1 / CXCR4 interaction is the activation of transcription factors such as AP-1 and chemokine regulated genes. JAK / STAT pathways also play a role in SDF-1/CXCR4 signaling.

CD184 (also known as CXCR4, or Fusin) is a seven-transmembrane domain G protein-coupled surface receptor. Its natural ligand is the stromal cell-derived factor-1 (SDF-1), a C-X-C chemokine which is strongly chemotactic for monocytes and lymphocytes. CD184 has initially been described as the human immunodeficiency virus-1 (HIV-1) entry co-receptor, associated with the surface CD4-gp120 complex before HIV-1 enters target cells. It also acts as an alternative receptor for some isolates of HIV-2. The SDF-1 / CD184 pair may also play a role in the development of the nervous system. Unlike other chemokine receptors, the cellular distribution of CD184 (CXCR4) is nearly ubiquitous; it is expressed on a variety of CD4+ and CD4– cells in the immune system and the central nervous system. In blood, CD184 is highly expressed on neutrophils, monocytes, dendritic cells, NK cells, B cells, and T cells, as well as on platelets. CD184 exhibits a rapid (30 seconds) up-regulation upon activation of lymphocytes, followed by internalization (within 2 minutes). Accordingly, CD184 is detected in large amounts in intracellular stores within leucocytes. Absent from eosinophils and basophils in fresh whole blood, this antigen is inducible ex vivo on eosinophils by glucocorticoids, and on basophils by SDF-1. As a GPCR, CXCR4 binding of SDF-1 triggers certain signaling pathways such as ras, and PI3 kinase. One downstream effect of SDF-1 / CD184 interaction is the activation of transcription factors such as AP-1 and chemokine regulated genes. JAK / STAT pathways also play a role in SDF-1/CXCR4 signaling.

The 12G5 antibody partially inhibits chemotaxis and calcium influx induced by SDF-1. It stains predominantly the naïve, resting CD26low CD45RA+ CD45R0- T lymphocyte subset of peripheral blood T cells. The 12G5 mAb has been assigned to the CD184 cluster of differentiation during HLDA 7.

A07409, CD184-PE Conjugated Antibody, 12G5, 2 mL, ASR

CD184 (also known as CXCR4, or Fusin) is a seven-transmembrane domain G protein-coupled surface receptor. CD184 (CXCR4) natural ligand is the stromal cell-derived factor-1 (SDF-1).

Learn more about this product on Beckman.com

CD184-PE, 12G5, 2 mL, ASR